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Product · Alignment & reference concordance

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IonConcord

Compare a delivered lot with the material you approved.

IonConcord compares an integrated peak list against your reference collection, corrects retention-time drift, and reports every matched, missing, shifted, and unexpected peak.

See how it works Evaluate with your data
IonConcord / signal explorerIllustrative data
From drift to a clear comparison

Two traces.
Differences revealed.

Align the sample. See the difference that remains.

Reference Sample Extra peak
Comparing sample and reference
Platform
macOS 13.3+ + no-install browser build
Primary input
Integrated peak-list CSV or TXT
References
Folder or ZIP of peak lists
Network
Not required

The problem

A specification says less than a reference does.

A specification checks a small set of marker compounds. A real reference contains the full pattern: majors, traces, absences, and the relationships between them.

IonConcord aligns a sample to that real reference, then classifies each difference. The result is evidence for a decision—not a black-box verdict.

03PROCESS08 INSPECTABLE STAGES

How it works

From two peak lists to a documented decision.

Each stage produces something you can inspect before the next one runs.

  1. 01

    Load the sample

    Read an integrated CSV or TXT peak list using the header rather than assuming fixed column positions.

    → Parsed sample peak list
  2. 02

    Load references

    Open a folder or ZIP of retained samples, approved lots, supplier references, or previous production.

    → Candidate library
  3. 03

    Rank candidates

    Compare the sample with the whole collection and order references by concordance.

    → Ranked candidate list
  4. 04

    Discover anchors

    Use shared compound identities first, then the peak pattern where identities are missing or ambiguous.

    → Anchor set
  5. 05

    Fit RT alignment

    Fit a linear, quadratic, or cubic relationship and derive the matching window from its residuals.

    → RT model + matching window
  6. 06

    Assign peaks

    Pair peaks monotonically so matches cannot cross in crowded chromatographic regions.

    → Peak-to-peak assignment
  7. 07

    Score & classify

    Separate matched, outside-tolerance, weak, missing, and extra peaks with settings recorded.

    → Concordance breakdown
  8. 08

    Report

    Show predicted and observed RT, RI, area percentages, and a reason for every exception.

    → Aligned CSV + differences-only PDF
04OUTPUTWHAT YOU GET

Evidence, not a verdict

The score opens into the finding.

01

A score you can inspect

Matched, outside-tolerance, weak, missing, and extra peaks remain visible beneath the headline number.

02

A reproducible comparison

RT window, minimum area, area tolerances, renormalisation, polynomial degree, and anchor strategy travel with the result.

03

A batch-ready record

Export the full aligned table or a differences-only PDF short enough to place in the batch file.

Limits worth stating

Clear about what the software does—and what it does not.

Concordance supports a laboratory decision; it does not release or reject a material automatically.

Defaults are starting points and must be validated for the material, instrument, and method.

Poor anchor coverage or a poor RT fit is a reason to inspect the chromatography before trusting the comparison.

Runs locally No upload Portable files
IonConcord / next step

Test it on the chromatogram that raised the question.

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